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Technical Information   Posters   Papers

Application #:
TI0930
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Column Performance
Compounds:
bifenthrin
etoxazole
fipronil
pridaben
Column(s):
Cadenza CD-C18 (50 x 2.0mm)
Unison UK-C18 (50 x 2.0mm)

LC-MS/MS: Insecticides

Application #:
TI0928
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Column Performance
Compounds:
Fipronil
Column(s):
Cadenza CD-C18 (50 x 2.0mm)
Unison UK-C18 (50 x 2.0mm)

LC-MS/MS: Insecticide (Fipronil)

Application #:
TI0918
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Food Chemistry
Synthetic Polymers
Compounds:
Poly-L-lysine
Column(s):
(250 x 4.6mm)

SEC: Polylysine

Application #:
TI0916
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Botanicals
Proteins
Compounds:
Lectin (Concanavalin A)
Column(s):
(250 x 4.6mm)

SEC: Lectin (Concanavalin A)

Application #:
TI0915
Type:
Application Note
Categories:
Synthetic Polymers
Pharmaceuticals and Cosmetics
Column Performance
Compounds:
Poly(lactic-co-glycolic acid) (PLGA)
Column(s):
(250 x 4.6mm)

SEC: PLGA, Poly(lactic-co-glycolic acid)

Application #:
TI0914
Type:
Application Note
Categories:
Synthetic Polymers
Pharmaceuticals and Cosmetics
Compounds:
Poly(lactic-co-glycolic acid) (PLGA)
Column(s):
(250 x 4.6mm)

SEC: PLGA, Poly(lactic-co-glycolic acid)

Application #:
TI0911
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Polysaccharides
Food Chemistry
Compounds:
Pectin
Column(s):
(250 x 4.6mm)

SEC: Pectin

Application #:
TI0910
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Polysaccharides
Food Chemistry
Compounds:
Mannan
Column(s):
(250 x 4.6mm)

SEC: Mannan

Application #:
TI0909
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Polysaccharides
Food Chemistry
Compounds:
Fucoidan
Column(s):
(250 x 4.6mm)

SEC: Fucoidan

Application #:
TI0908
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Polysaccharides
Food Chemistry
Compounds:
hyaluronic acid
Column(s):
(250 x 4.6mm)

SEC: hyaluronic acid, sodium salt

Application #:
TI0905
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Polysaccharides
Compounds:
Hydroxypropyl cellulose
Column(s):
(250 x 4.6mm)

SEC: Hydroxypropyl cellulose (HPC)

Application #:
TI0903
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Polysaccharides
Compounds:
Dextran
Column(s):
(250 x 4.6mm)

SEC: Dextran

Application #:
TI0902
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Polysaccharides
Compounds:
Dextran sulfate
Column(s):
(250 x 4.6mm)

SEC: Dextran sulfate, sodium salt

Application #:
TI0901
Type:
Application Note
Categories:
Biochemistry/Metabolism
Proteins
Food Chemistry
Pharmaceuticals and Cosmetics
Compounds:
Poly-gamma-glutamic acid
Column(s):
(250 x 4.6mm)

SEC: Poly-gamma-glutamic acid

Application #:
TI0896
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Proteins
Food Chemistry
Compounds:
Collagen Peptide
Column(s):
(250 x 4.6mm)

SEC: Collagenpeptide

Application #:
TI0890
Type:
Application Note
Categories:
Oligosaccharides
Pharmaceuticals and Cosmetics
Compounds:
Pullulan
Column(s):
(250 x 4.6mm)

Pullulan

Application #:
TI0888
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
Diethylamino hydroxybenzoyl hexyl benzoate
Octocrylene (2-ethylhexyl 2-cyano-3
3-diphenyl-2-propenoate
Ethylhexyl methoxycinnamate
2-Ethylhexyl salicylate
Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine
Column(s):
Unison UK-C8 (150 x 4.6mm)

Sunscreen compounds

Application #:
TI0884
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Botanicals
Steroids
Compounds:
Matrine
Oxymatrine
Column(s):
Cadenza 5CD-C18 (250 x 4.6mm)

Alkaloids, Matrine and Oxymatrine

Application #:
TI0883
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Biochemistry/Metabolism
Compounds:
Histamine
Column(s):
Scherzo SM-C18 (150 x 4.6mm)

Histamine

Application #:
TI0882
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Botanicals
Steroids
Compounds:
R1
Rg1
Re
Rf
Rb1
Rg2
Rh1
Rc
Rb2
Rb3
Rd
Rg3
Compound K
Rh2
Column(s):
Cadenza CD-C18 (150 x 3.0mm)

Ginsenoside

Application #:
TI0881
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
ephedrine
atropine
Column(s):
Cadenza CD-C18 (250 x 4.6mm)

ephedrine, atropine

Application #:
TI0880
Type:
Application Note
Categories:
Industrial Chemical
Pharmaceuticals and Cosmetics
Compounds:
DMF
DMSO
Column(s):
Unison UK-Silica (250 x 4.6mm)

DMF (dimethyl formamide), DMSO (dimethyl sulfoxide)

Application #:
TI0857
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
taxifolin
Column(s):
Cadenza CD-C18 (50 x 3.0mm)
Unison UK-C8 (50 x 3.0mm)

LC-MS: Taxifolin

Application #:
TI0842
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
doxylamine
risperidone
olanzapine
Column(s):
Unison UK-C18 (100 x 3.0mm)
Unison UK-C8 (100 x 3.0mm)
Unison UK-Phenyl (100 x 3.0mm)

LC-MS: Antipsychotics

Application #:
TI0841
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
doxylamine
risperidone
olanzapine
Column(s):
Scherzo SW-C18 (100 x 3.0mm)

LC-MS: Antipsychotics

Application #:
TI0838
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
vancomycin
Column(s):
Unison UK-C18 (50 x 4.6mm)

Antibiotic (vancomycin)

Application #:
TI0836
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
sumatriptan
zolmitriptan
eletriptan
Column(s):
Unison UK-C18 (100 x 3.0mm)
Unison UK-Phenyl (100 x 3.0mm)

LC-MS: antimigraines (selective serotonin agonists)

Application #:
TI0835
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
sumatriptan
zolmitriptan
eletriptan
Column(s):
Unison UK-C18 (100 x 3.0mm)
Unison UK-Phenyl (100 x 3.0mm)

LC-MS: antimigraines (selective serotonin agonists)

Application #:
TI0833
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
methylparaben
ethylparaben
isopropylparaben
propylparaben
isobutylparaben
butylparaben
Column(s):

Paraben isomers

Application #:
TI0832
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
sumatriptan
zolmitriptan
eletriptan
Column(s):
Scherzo SW-C18 (100 x 3.0mm)

LC-MS: antimigraines (selective serotonin agonists)

Application #:
TI0828
Type:
Application Note
Categories:
LC-MS
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
doxepine
Column(s):

LC-MS: Basic compound (mobile phase pH)

Application #:
TI0827
Type:
Application Note
Categories:
LC-MS
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
scoporamine
physostigmine
Column(s):

LC-MS: Alkaloids (alkali conditions)

Application #:
TI0826
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals and Cosmetics
Compounds:
doxepine
imipramine
trimipramine
Column(s):

Tricyclic antidepressants

Application #:
TI0729
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
4-fluoroamphetamine 4-FMP
3-fluoroamphetamine 3-FMP
2-fluoroamphetamine 2-FMP
4-fluoromethamphetamine N-methyl-4-FMP
3-fluoromethamphetamine N-methyl-3-FMP
2-fluoromethamphetamine N-methyl-2-FMP
Column(s):
Unison UK-Phenyl (150 x 3.0mm)

The Unison UK-Phenyl column effectively separates fluoroamphetamine and fluoromethamphetamine isomers with identical mass.

Application #:
TI0728
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
Triazolam
etizolam
8OH-etizolam
1OH-etizolam
4OH-triazolam
1OH-triazolam
Column(s):
Unison UK-Phenyl (150 x 2.0mm)

The Unison UK-Phenyl column is effectively able to separate triazolam and etizolam, which are very similar in structure.

Application #:
TI0709
Type:
Application Note
Categories:
Pharmaceutical and Cosmetics
DNA related compounds
Column Performance
Compounds:
uracil
isopropylparaben
propylparaben
butylparaben
Column(s):
Cadenza CD-C18 (100 x 4.6mm)

The Cadenza CD-C18 HT 3 micron column shows comparable resolution to a sub-2 micron column, with much lower pressure.

Application #:
TI0708
Type:
Application Note
Categories:
Pharmaceutical and Cosmetics
DNA related compounds
Column Performance
Compounds:
uracil
isopropylparaben
propylparaben
butylparaben
Column(s):
Cadenza CD-C18 (150 x 4.6mm)

The Cadenza CD-C18 HT 3 micron column shows better resolution between isopropylparaben and propylparaben than a sub-2 micron column, and the CD-C18 HT column also shows a higher plate count.

Application #:
TI0707
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
DNA related compounds
Column Performance
Compounds:
uracil
isopropylparaben
propylparaben
butylparaben
Column(s):
Cadenza CD-C18 (150 x 4.6mm)

The Cadenza CD-C18 HT 3 micron column shows lower pressure, higher plate count, and higher resolution than a sub-2 micron column.

Application #:
TI0706
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
Tadalafil
Sildenafil and Vardenafil
Column(s):
Unison UK-C18 (75 x 2.0mm)

Tadalafil, Sildenafil, and Vardenafil are all polar small molecules that are easily separated on the Unison UK-C18 HT column. Not only are the slight structural differences between Sildenafil and Vardenafil recognized by the column, but it also separates all three compounds within 1.5 minutes.

Application #:
TI0701
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Botanicals
Biochemistry/Metabolism
Compounds:
Allantoin
allantoic acid and uric acid
Column(s):
Scherzo SW-C18 (250 x 3.0mm)
Scherzo SM-C18 (250 x 3.0mm)
Scherzo SS-C18 (250 x 3.0mm)
Unison UK-C18 (250 x 3.0mm)

The Scherzo SM-C18 and the Scherzo SW-C18 show similar retention of these small molecules as the standard Unison UK-C18. However, the Scherzo SS-C18 shows the best resolution between these three compounds.

Application #:
TI0690
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
Ibuprofen
Chlorpheniramine
Column(s):
Scherzo SW-C18 (150 x 4.6mm)
Scherzo SM-C18 (150 x 4.6mm)

Both Scherzo SM-C18 and Scherzo SW-C18 can separate an acidic compound (Ibuprofen) and a basic compound (Chlorpheniramine) at the same time. Scherzo SW-C18 works better under gradient elution, whereas Scherzo SM-C18 works better under isocratic elution.

Application #:
TI0689
Type:
Application Note
Categories:
Botanicals
Pharmaceuticals and Cosmetics
Compounds:
trans-resveratrol
cis-resveratrol
Column(s):
Scherzo SM-C18 (150 x 3.0mm)
Cadenza CD-C18 (150 x 3.0mm)
Cadenza CW-C18 (150 x 3.0mm)
Cadenza CL-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)
Presto FF-C18 (150 x 3.0mm)

All of the columns listed can recognize the structural difference between these two isomers, and resolve them into two separate peaks.

Application #:
TI0686
Type:
Application Note
Categories:
Proteins
Industrial Chemical
Pharmaceuticals and Cosmetics
Compounds:
collagen from pig skin
Column(s):
Intrada WP-RP (250 x 4.6mm)
Presto FF-C18 (250 x 4.6mm)

Both Presto FF-C18 and Intrada WP-RP can elute this large protein. Intrada WP-RP shows sharper peaks, meaning it can better recognize its structural components than Presto FF-C18.

Application #:
TI0679
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
" acetaminophen
N-acetyl-4-benzoquinone imine"
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)
Cadenza CL-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

Acetaminophen and metabolite

Application #:
TI0678
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
" acetaminophen
N-acetyl-4-benzoquinone imine"
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)
Cadenza CL-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

Acetaminophen and metabolite

Application #:
TI0676
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
LC-MS
Compounds:
nifedipine
warfarin
diclofenac
2-amino-5-chlorobenzophenone
Column(s):
Cadenza CD-C18 (50 x 2.0mm)

Ultra-high throughput LC-MS/MS analysis of drugs in blood plasma

Application #:
TI0672
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
phenylephrine
N-acetylprocainamide
procaine
naphazoline
Column(s):
Scherzo SW-C18 (150 x 3.0mm)

Basic pharmaceutical compounds

Application #:
TI0669
Type:
Application Note
Categories:
Biochemistry/Metabolism
Pharmaceuticals and Cosmetics
Compounds:
gamma-aminobutyric acid (GABA)
D
L-noradrenaline ((D
L-norepinephrine)
D
L-adrenaline (D
L-epinephrine)
3
4-dihydroxy-L-phenylalanine (L-DOPA)
dopamine
Column(s):
Scherzo SW-C18 (150 x 3.0mm)
Scherzo SM-C18 (150 x 3.0mm)
Scherzo SS-C18 (150 x 3.0mm)

Catecholamines

Application #:
TI0662
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
penicillin G
methicillin
ampicillin
amoxicillin
carbenicillin
Column(s):
Scherzo SM-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)

Penicillin Antibiotics

Application #:
TI0658
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
chloramphenicol (CP)
Column(s):
Cadenza CD-C18 (150 x 2.0mm)

LC-MS/MS analysis of chloramphenicol (CP)

Application #:
TI0656
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
clenbuterol
Column(s):
Cadenza CD-C18 (150 x 2.0mm)

LC-MS/MS analysis of clenbuterol (CBR)

Application #:
TI0655
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Compounds:
3-amino-5-morpholinomethyl-2oxazolidinone
3-amino-2-oxazolidinone
1-aminohydantionq
Column(s):
Cadenza CD-C18 (150 x 2.0mm)

LC/MS analysis of nitrofurans metabolites (AOZ, AMOZ, AHD)

Application #:
TI0640
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
dl-chlorpheniramine
dextromethorphan
propylparaben
Column(s):
Scherzo SM-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

Cold medicine compounds

Application #:
TI0639
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
dl-chlorpheniramine
dextromethorphan
propylparaben
Column(s):
Cadenza CD-C18 (150 x 4.6mm)
Cadenza CW-C18 (150 x 4.6mm)
Unison UK-C18 (150 x 4.6mm)
Unison UK-C8 (150 x 4.6mm)
Unison UK-Phenyl (150 x 4.6mm)

Cold medicine compounds

Application #:
TI0628
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
esculin
esculetin
hydroxycoumarin
scopoletin
coumarin
dihydrocoumarin
warfarin
Column(s):
Scherzo SM-C18 (150 x 4.6mm)

Coumarins

Application #:
TI0621
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
plerixafor
Column(s):
Unison UK-C18 (150 x 4.6mm)

Plerixafor (Chemokine receptor antagonist)

Application #:
TI0610
Type:
Application Note
Categories:
Industrial Chemical
Pharmaceuticals & Cosmetics
Compounds:
zinc pyrithione
copper pyrithione
Column(s):
Unison UK-Phenyl (50 x 3.0mm)

Zinc Pyrithione, Copper Pyrithione

Application #:
TI0609
Type:
Application Note
Categories:
Industrial Chemical
Pharmaceuticals & Cosmetics
Compounds:
chromium
copper
zinc
magnesium
calcium
potassium
sodium
Column(s):
Scherzo SM-C18 (150 x 3.0mm)

Cations

Application #:
TI0604
Type:
Application Note
Categories:
Synthetic Polymers
Pharmaceuticals & Cosmetics
Compounds:
poly (DL-lactide)
poly (DL-lactide-co-glycolide)
Column(s):
Presto FF-C18 (30 x 4.6mm)

Biodegradable polymer ( poly (DL-lactide) and poly (DL-lactide-co-glycolide) )

Application #:
TI0603
Type:
Application Note
Categories:
Synthetic Polymers
Pharmaceuticals & Cosmetics
Compounds:
poly (DL-lactide)
poly (DL-lactide-co-glycolide)
Column(s):
Unison UK-Amino (150 x 3.0mm)

Biodegradable polymer ( poly (DL-lactide) and poly (DL-lactide-co-glycolide) )

Application #:
TI0602
Type:
Application Note
Categories:
Synthetic Polymers
Pharmaceuticals & Cosmetics
Compounds:
poly (DL-lactide)
poly (DL-lactide-co-glycolide)
Column(s):
Cadenza CW-C18 (150 x 3.0mm)

Biodegradable polymer ( poly (DL-lactide) and poly (DL-lactide-co-glycolide) )

Application #:
TI0593
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
plerixafor
Column(s):
Unison UK-C18 (150 x 4.6mm)

Plerixafor (Chemokine receptor antagonist)

Application #:
TI0592
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
cetirizine
Column(s):
Scherzo SM-C18 (150 x 4.6mm)
Cadenza CD-C18 (150 x 4.6mm)
Cadenza CW-C18 (150 x 4.6mm)
Cadenza CL-C18 (150 x 4.6mm)
Cadenza HS-C18 (150 x 4.6mm)
Unison UK-C18 (150 x 4.6mm)
Unison UK-C8 (150 x 4.6mm)
Unison UK-Phenyl (150 x 4.6mm)

Cetirizine (Antihistamine)

Application #:
TI0545
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Probucol
Column(s):
Cadenza HS-C18 (150 x 3.0mm)

Anti-hyperlipidemic drug in bovine serum (probucol)

Application #:
TI0544
Type:
Application Note
Categories:
Industrial Chemical
Pharmaceuticals & Cosmetics
Compounds:
Benzathonium chloride
Column(s):
Scherzo SM-C18 (250 x 3.0mm)
Unison UK-C18 (250 x 3.0mm)

Benzathonium chloride

Application #:
TI0543
Type:
Application Note
Categories:
Industrial Chemical
Pharmaceuticals & Cosmetics
Compounds:
benzalkonium chloride
Column(s):
Scherzo SM-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

Benzalkonium chloride

Application #:
TI0537
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
streptomycin sulfate
amikacin disulfate
kanamycin sulfate
tobramycin sulfate
gentamicin sulfate
Column(s):
Scherzo SM-C18 (150 x 3.0mm)

Aminoglycoside antibiotics

Application #:
TI0536
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Biochemistry / Metabolism
Compounds:
N-methylhydantoin
methimazole
N-methylthiourea
2-mercaptoimidazole
Column(s):
Unison UK-Amino (250 x 3.0mm)

Methimazole and potential metabolites

Application #:
TI0535
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Botanicals
Saccharides
Compounds:
nojirimycin bisulfite
1-deoxynojirimycin hydrochloride
1-deoxymannojirimycin hydrochloride
Column(s):
Scherzo SM-C18 (250 x 4.6mm)

Nojirimycin relative compounds

Application #:
TI0534
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
hydroxyzine
pamoic acid
Column(s):
Scherzo SM-C18 (50 x 3.0mm)
Unison UK-C18 (50 x 3.0mm)

Hydroxyzine pamoate

Application #:
TI0533
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
fumaric acid
clemastine
Column(s):
Scherzo SM-C18 (50 x 3.0mm)
Unison UK-C18 (50 x 3.0mm)

Clemastine fumarate

Application #:
TI0532
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
tipepidine
hibenzic acid
Column(s):
Scherzo SM-C18 (50 x 3.0mm)

Tipepidine hibenzate

Application #:
TI0531
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
maleic acid
dl-chlorpheniramine
Column(s):
Scherzo SM-C18 (50 x 3.0mm)

Chlorpheniramine maleate

Application #:
TI0525
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
doxepine
desipramine
imipramine
nortriptyline
amitriptyline
trimipramine
Column(s):
Scherzo SM-C18 (150 x 3.0mm)

Basic compounds: Antidepressant drugs

Application #:
TI0520
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Biochemistry / Metabolism
Compounds:
sodium chloride
Column(s):
Scherzo SM-C18 (150 x 3.0mm)

Sodium Chloride

Application #:
TI0511
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Zanamivir (Anti-flu medicine)
Column(s):
Unison UK-C18 (150 x 4.6mm)
Unison UK-Silica (150 x 4.6mm)
Unison UK-Amino (150 x 4.6mm)

Zanamivir (Anti-flu medicine)

Application #:
TI0510
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Oseltamivir phosphate (Anti-flu medicine)
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison US-C18 (150 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Oseltamivir phosphate (Anti-flu medicine)

Application #:
TI0509
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Paroxetine HCl (Antidepressant)
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison US-C18 (150 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Paroxetine HCl (Antidepressant)

Application #:
TI0508
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Rilmazafone HCl (Benzodiazepine hypnotic)
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison US-C18 (150 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Rilmazafone HCl (Benzodiazepine hypnotic)

Application #:
TI0507
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Zopiclone (Nonbenzodiazepine hypnotic)
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison US-C18 (150 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Zopiclone (Nonbenzodiazepine hypnotic)

Application #:
TI0506
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Codeine phosphate (Narcotic antitussive)
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison US-C18 (150 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Codeine phosphate (Narcotic antitussive)

Application #:
TI0502
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Column Performance
Compounds:
phenyltrimethylammnonium
benzenesulfonic acid
benzamide
Column(s):
Scherzo SM-C18 (150 x 3.0mm)

The Scherzo SM-C18 column shows excellent batch to batch reproducibility for anionic, cationic, and neutral compounds.

Application #:
TI0500
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Steroids
Column Performance
Compounds:
acetaminophen
1-hydroxyN 7-azabenzotriazole
prednisolone
methyl 3-aminoS 2-thiophenecarboxylate
6-alphamethylprednisolone
corticosterone
4-aminobenzophenone
propylparaben
Column(s):
Scherzo SM-C18 (75 x 4.6mm)

The Scherzo SM-C18 column shows excellent batch to batch reproducibility for these small polar molecules.

Application #:
TI0499
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Pranoprofen (Nonsteroid anti-inflammatory drug:NSAID)
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison US-C18 (150 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Pranoprofen (Nonsteroid anti-inflammatory drug:NSAID)

Application #:
TI0498
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Naftopidil (alpha1-receptor blocker)
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison US-C18 (150 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Naftopidil (alpha1-receptor blocker)

Application #:
TI0497
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Furosemide (Diuretic)
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison US-C18 (150 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Furosemide (Diuretic)

Application #:
TI0496
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Menatetrenone (Vitamin K)
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison US-C18 (150 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Menatetrenone (Vitamin K)

Application #:
TI0495
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Mequitazine
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison US-C18 (150 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Mequitazine (Antihistamine)

Application #:
TI0494
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics / Steroids
Compounds:
Betamethasone
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison US-C18 (150 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Betamethasone (Antihistamine:Adrenal corticosteroid)

Application #:
TI0463
Type:
Application Note
Categories:
Pharmaceuticals and Cosmetics
Compounds:
Duloxetine
Ethyl Morphine
Column(s):
Unison US-C18 (50 x 2.0mm)

LC-MS/MS Application for Duloxetine and Ethyl Morphine in Whole Blood

Application #:
TI0458
Type:
Application Note
Categories:
Industrial Chemicals
Pharmaceuticals & Cosmetics
Compounds:
ethylenediamine
diethylenetriamine
triethylenetetramine
tetraethylenepentamine
Column(s):
Unison UK-C18 (75 x 3.0mm)

Aliphatic Amines

Application #:
TI0450
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Column Performance
Compounds:
propranolol
Column(s):
Unison US-C18 (150 x 4.6mm)

Propranolol

Application #:
TI0436
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
vancomycin
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CW-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)

Antibiotic (Vancomycin)

Application #:
TI0435
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
tylosin
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CW-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)

Antibiotic (Tylosin)

Application #:
TI0434
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
rifampicin
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CW-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)

Antibiotic (Rifampicin)

Application #:
TI0432
Type:
Application Note
Categories:
Saccharides
Botanicals
Pharmaceuticals & Cosmetics
Compounds:
nojirimycin bisulfite
1-deoxynojirimycin hydrochloride
1-deoxymannojirimycin hydrochloride
Column(s):
Unison UK-Amino (30 x 3.0mm)

Nojirimycin Relative Compounds

Application #:
TI0431
Type:
Application Note
Categories:
Saccharides
Botanicals
Pharmaceuticals & Cosmetics
Compounds:
D-glucose
1-deoxynojirimycin hydrochloride
Column(s):
Unison UK-Amino (250 x 3.0mm)

Deoxynojirimycin, Glucose

Application #:
TI0428
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
erythromycin
Column(s):
Cadenza CD-C18 (150 x 4.6mm)
Cadenza CW-C18 (150 x 4.6mm)

Antibiotic (Erythromycin)

Application #:
TI0427
Type:
Application Note
Categories:
Amino Acids and Peptides
Pharmaceuticals & Cosmetics
Compounds:
Polymyxin B
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CW-C18 (75 x 3.0mm)

Polypeptide Antibiotic (2) - Polymyxin B

Application #:
TI0426
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
tobramycin sulfate
streptomycin sulfate
kanamycin sulfate
gentamicin sulfate
amikacin disulfate
Column(s):
Cadenza CD-C18 (250 x 3.0mm)
Cadenza CW-C18 (250 x 3.0mm)
Cadenza CL-C18 (250 x 3.0mm)
Unison UK-C18 (250 x 3.0mm)

Aminoglycoside Antibiotics

Application #:
TI0422
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
acyclovir
lactose
Column(s):
Unison UK-Amino (50 x 3.0mm)

Acyclovir and Lactose

Application #:
TI0417
Type:
Application Note
Categories:
Biochemistry / Metabolism
Pharmaceuticals & Cosmetics
Compounds:
theophylline
theobromine
caffeine
beta-(7-hydroxyethyl) theophylline
3-propylxanthine
1-methylxanthine
Column(s):
Unison UK-Amino (100 x 3.0mm)

Xanthines and Metabolites

Application #:
TI0415
Type:
Application Note
Categories:
Biochemistry / Metabolism
Pharmaceuticals & Cosmetics
Compounds:
theophylline
theobromine
caffeine
beta-(7-hydroxyethyl) theophylline
3-propylxanthine
1-methylxanthine
Column(s):
Cadenza 5CD-C18 (75 x 2.0mm)
Cadenza CW-C18 (75 x 2.0mm)
Unison US-C18 (150 x 4.6mm)

Xanthines and Metabolites

Application #:
TI0411
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals & Cosmetics
Compounds:
tetracycline
oxytetracycline
chlortetracycline
Column(s):
Cadenza CW-C18 (100 x 2.0mm)

LC-MS/MS Application -Tetracycline Antibiotics

Application #:
TI0410
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
tetracycline (TC)
oxytetracycline (OTC)
chlortetracycline (CTC)
Column(s):
Cadenza CW-C18 (150 x 4.6mm)

Tetracycline antibiotics

Application #:
TI0409
Type:
Application Note
Categories:
Biochemistry / Metabolism
Pharmaceuticals & Cosmetics
Compounds:
uracil
dihydrouracil
dihydrofluorouracil
5-fluorouracil
Column(s):
Unison UK-Phenyl (250 x 4.6mm)
Unison UK-Amino (250 x 3.0mm)

5-Fluorouracil and Related Compounds

Application #:
TI0403
Type:
Application Note
Categories:
Industrial Chemicals
Food Chemistry
Pharmaceuticals & Cosmetics
Compounds:
n-propyl gallate
nordihydroguaiaretic acid
n-octyl gallate
n-dodecyl gallate
butylhydroxytoluene
butylhydroquinone
4-hydroxy-3-t-butylanisole
2
6-di-tert-butyl-4-hydroxymethylphenol
Column(s):
Cadenza CD-C18 (50 x 2.0mm)
Cadenza 5CD-C18 (150 x 4.6mm)
Cadenza 5CD-C18 (150 x 4.6mm)

Antioxidants

Application #:
TI0402
Type:
Application Note
Categories:
Saccharides
Pharmaceuticals & Cosmetics
Oligosaccharides
Compounds:
voglibose
acarbose
Column(s):
Unison UK-Amino (250 x 3.0mm)
Unison UK-Amino (250 x 4.6mm)

Voglibose, Acarbose

Application #:
TI0399
Type:
Application Note
Categories:
Amino Acids and Peptides
Pharmaceuticals & Cosmetics
Compounds:
bacitracin
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CW-C18 (75 x 4.6mm)

Polypeptide Antibiotic, bacitracin

Application #:
TI0398
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
trimipramine
nortriptyline
imipramine
doxepine
desipramine
amitriptyline
Column(s):
Cadenza CW-C18 (150 x 3.0mm)
Unison UK-C8 (150 x 3.0mm)

Basic Compounds: Antidepressant drug

Application #:
TI0395
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
polyvinylpyrrolidone K30 (PVP)
disopyramide
Column(s):
Cadenza HS-C18 (30 x 3.0mm)

Disopyramide in PVP Aqueous Solution

Application #:
TI0392
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
verapamil hydrochloride
hydroxypropylcellulose (HPC)
Column(s):
Cadenza HS-C18 (30 x 3.0mm)

The Cadenza HS-C18 column shows excellent exclusion of the large polymer HPC from the main sharp peak, verapamil.

Application #:
TI0391
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
cefalexin
carboxymethylcellulose sodium salt (CMC-Na)
Column(s):
Cadenza HS-C18 (30 x 3.0mm)

Cefalexin in CMC-Na Aqueous Solution

Application #:
TI0390
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
lidocaine
carboxymethylcellulose sodium salt (CMC-Na)
Column(s):
Cadenza HS-C18 (30 x 3.0mm)

Lidocaine in CMC-Na Aqueous Solution

Application #:
TI0389
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
sulfamethoxazole
sodium alginate
Column(s):
Cadenza HS-C18 (30 x 3.0mm)

Sulfamethoxazole in Alginate Aqueous Solution

Application #:
TI0388
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
calcitonin acetate
salmon (MW 3492)
Column(s):
Cadenza CD-C18 (100 x 3.0mm)
Cadenza CW-C18 (100 x 3.0mm)
Cadenza CL-C18 (100 x 3.0mm)
Unison UK-C18 (100 x 3.0mm)
Unison UK-Amino (100 x 3.0mm)

Calcitonin, salmon

Application #:
TI0387
Type:
Application Note
Categories:
Amino Acids and Peptides
Pharmaceuticals & Cosmetics
Compounds:
calcitonin acetate
salmon (MW 3492)
Column(s):
Cadenza HS-C18 (30 x 3.0mm)

Calcitonin in Gelatin Aqueous Solution

Application #:
TI0386
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
indomethacin
Column(s):
Cadenza HS-C18 (30 x 3.0mm)

Indomethacin in gelatin aqueous solution

Application #:
TI0372
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
cefdinir
cefalexin
cefaclor
Column(s):
Cadenza CD-C18 (50 x 3.0mm)
Unison UK-Amino (50 x 3.0mm)

Unison UK-Amino and Cadenza CD-C18 provide different selectivity for cephem antibiotics due to the difference in the stationary phase.

Application #:
TI0365
Type:
Application Note
Categories:
LC-MS
Pharmaceuticals & Cosmetics
Compounds:
oxymorphone
oxycodone
morphrine
hydromorphone
hydrocodone
codeine
6-acetyl morphine
Column(s):
Unison US-C18 (50 x 2.0mm)

Opiates of similar structure can be separated and analyzed by LC-MS. For example, morphine and oxymorphone are very similar but are resolved into two separate peaks.

Application #:
TI0303
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
minoxidil sulfate
minoxidil
Column(s):
Cadenza CD-C18 (150 x 4.6mm)
Cadenza CW-C18 (150 x 4.6mm)
Cadenza CL-C18 (150 x 4.6mm)
Cadenza HS-C18 (150 x 4.6mm)
Unison UK-C18 (150 x 4.6mm)
Unison UK-C8 (150 x 4.6mm)
Unison UK-Phenyl (150 x 4.6mm)

Minoxidil and metabolite

Application #:
TI0288
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
verapamil
progesterone
Column(s):
Cadenza CD-C18 (150 x 4.6mm)
Cadenza CL-C18 (150 x 4.6mm)
Cadenza HS-C18 (150 x 4.6mm)
Unison UK-C18 (150 x 4.6mm)

Verapamil

Application #:
TI0277
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
Morantel Citrate
Column(s):
Cadenza CD-C18 (150 x 4.6mm)
Cadenza HS-C18 (150 x 4.6mm)
Unison UK-C18 (150 x 4.6mm)

Morantel Citrate

Application #:
TI0276
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Column Performance
Compounds:
sulfisoxazole
sulfathiazole
sulfaquinoxaline
sulfamonomethoxine
sulfamethoxazole
sulfamethaxine
sulfamerazine
sulfadiazine
Column(s):
Cadenza CD-C18 (20 x 2.0mm)

HT sulfonamides

Application #:
TI0275
Type:
Application Note
Categories:
Industrial Chemicals
Pharmaceuticals & Cosmetics
Compounds:
phenylenediboronic acid
naphthaleneboronic acid
benezeneboronic acid
Column(s):
Cadenza CD-C18 (150 x 3.0mm)

Aromatic boronic acids

Application #:
TI0267
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
ddl (2'3'-dideoxyinosine)
d4T (2'3'-didehydro-3'-deoxythymidine)
AZT (azidothymidine)
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)

Anti-HIV nucleosides

Application #:
TI0264
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
scoporamine hydrobromide
butylscopalamine bromide
atropine sulfate
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)

Parasympatholytics

Application #:
TI0261
Type:
Application Note
Categories:
Industrial Chemicals
Food Chemistry
Pharmaceuticals & Cosmetics
Compounds:
Fe (III)-EDTA
EDTA disodium salt
Cu (II)-EDTA
Column(s):
Unison UK-Phenyl (75 x 4.6mm)

EDTA-Chelates

Application #:
TI0258
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
sulfisoxazole
sulfathiazole
sulfaquinoxaline
sulfamonomethoxine
sulfamethoxazole
sulfamethazine (sulfadimidin)
sulfamerazine
sulfadiazine
Column(s):
Cadenza CD-C18 (30 x 2.0mm)
Cadenza CL-C18 (30 x 2.0mm)
Unison UK-C18 (30 x 2.0mm)

Sulfonamides

Application #:
TI0256
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
phenylbutazone
oxyphenbutazone
naproxen
meclofenamic acid sodium salt
ketoprofen
flunixin
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)

NSAIDs

Application #:
TI0249
Type:
Application Note
Categories:
Pharmaceuticals & Cosmetics
Compounds:
chloropheniramine
maleate
allantoin
Column(s):
Unison UK-Silica (250 x 4.6mm)

Ingrediants in eye drops (allantoin and chlorpheniramine, maleate)

Application #:
TI0247
Type:
Application Note
Categories:
Column Performance
Pharmaceuticals & Cosmetics
Biochemistry / Metabolism
Compounds:
procainamide
N-acetylprocainamide
Column(s):
Cadenza CD-C18 (30 x 4.6mm)
Cadenza CL-C18 (30 x 4.6mm)

Separation properties of basic compounds on CL-C18

Application #:
TI0246
Type:
Application Note
Categories:
Column Performance
Biochemistry / Metabolism
Food Chemistry
Pharmaceuticals & Cosmetics
Compounds:
benzoic acid
salicylic acid
theophylline
phenol
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Cadenza CL-C18 (75 x 4.6mm)

Separation properties for acidic compounds on CL-C18

Application #:
TI0229
Type:
Application Note
Categories:
Synthetic Antimicrobial (Enrofloxacin)
Compounds:
enrofloxacin
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)

Enrofloxacin

Application #:
TI0224
Type:
Application Note
Categories:
Natural Medicine Properties (Shoseiryuto)
Compounds:
paeoniflorin
d-pseudoephedrine
l-ephedrine
Column(s):
Cadenza CD-C18 (75 x 4.6mm)

Analysis of components of Shoseiryuto, an herbal medication, including paeoniflorin and ephedrine.

Application #:
TI0223
Type:
Application Note
Categories:
Veterinary Medicine (Synthetic Antimicrobial)
Compounds:
thiamphenicol
levamisol
oxolinic acid
nifurstyreneate monosodium salt
Column(s):
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Four synthetic antibacterial veterinary medications were separated using various columns. Using gradient elution and TFA modifier, the best separation was achieved using a phenyl and C8 phase.

Application #:
TI0222
Type:
Application Note
Categories:
Antibiotic
Compounds:
bacitracin
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of the annular peptide antibiotic bacitracin using various reverse phase columns. Each column produces excellent peaks using gradient elution and TFA modifier.

Application #:
TI0221
Type:
Application Note
Categories:
Antibiotic
Compounds:
colistin
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of the annular peptide antibiotic colistin, which targets the plasma membrane of gram negative bacteria, using various reverse phase columns. All columns achieve excellent separation of colistin isotomers using gradient elution and TFA modifier.

Application #:
TI0220
Type:
Application Note
Categories:
Antibiotic
Compounds:
spiramycin
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of the macrolide antibiotic spiramycin using various reverse phase columns. Each column produces a sharp peak with TFA mobile phase.

Application #:
TI0219
Type:
Application Note
Categories:
Antibiotic
Compounds:
erythromycin
Column(s):
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of the macrolide antibiotic erythromycin using various reverse phase columns. Each column produces a sharp peak at neutral pH.

Application #:
TI0218
Type:
Application Note
Categories:
Veterinary Medicine (Synthetic Antimicrobial)
Compounds:
salinomycin
Column(s):
Unison UK-C18 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of salinomycin, a common antibiotic additive to animal feed. Note the incredible peak produced by the UK Phenyl column.

Application #:
TI0217
Type:
Application Note
Categories:
Veterinary Medicine (Synthetic Antimicrobial)
Compounds:
lasalocid
Column(s):
Unison UK-C18 (75 x 3.0mm)
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of lasalocid, a common antibiotic additive to animal feed, in acid. Each column produces an excellent peak.

Application #:
TI0216
Type:
Application Note
Categories:
Antibiotic
Compounds:
oxytetracycline
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of the antibiotic oxytetracycline, which impedes protein synthesis, using various reverse phase columns. Excellent peaks are produced by all columns in acidic conditions.

Application #:
TI0215
Type:
Application Note
Categories:
Antibiotic
Compounds:
ampicillin
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of penicillin, which impedes synthesis of the bacterial cell wall, using various reverse phase columns. Under acidic conditions all columns produce excellent peaks.

Application #:
TI0214
Type:
Application Note
Categories:
Antibiotic
Compounds:
lincomycin
Column(s):
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Reverse phase separation of the gram negative antibiotic lincomycin in acid produces an excellent peak.

Application #:
TI0213
Type:
Application Note
Categories:
Synthetic Antimicrobial
Compounds:
thiamphenicol
Column(s):
Unison UK-C18 (75 x 3.0mm)
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of the synthetic veterinary antibiotic thiamphenicol, which impedes protein synthesis, under neutral pH. The C18, C8 and Phenyl columns all produce excellent peaks.

Application #:
TI0212
Type:
Application Note
Categories:
Veterinary Medicine (Synthetic Antimicrobial)
Compounds:
levamisol
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of the anthelminthic veterinary drug levamisol. Our reverse phase column with superior end-capping produces excellent peaks under neutral conditions.

Application #:
TI0211
Type:
Application Note
Categories:
Veterinary Medicine (Synthetic Antimicrobial)
Compounds:
oxolinic acid
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of the veterinary antimicrobrial oxolinic acid produces excellent peaks with various reverse phase columns.

Application #:
TI0210
Type:
Application Note
Categories:
Veterinary Medicine (Synthetic Antimicrobial)
Compounds:
nifurstyreneate monosodium salt (NFS)
Column(s):
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CL-C18 (75 x 3.0mm)
Unison UK-C18 (75 x 3.0mm)
Unison UK-C8 (75 x 3.0mm)
Unison UK-Phenyl (75 x 3.0mm)

Analysis of nifurstyreneate monosodium salt, a veterinary antimicrobial nitrofuran used on fish, using various reverse phase columns.

Application #:
TI0209
Type:
Application Note
Categories:
DMSO
Compounds:
dimethyl sulfoxide (DMSO)
Column(s):
Unison UK-Silica (150 x 3.0mm)

The reverse phase separation of the hydrophillic organic solvent dimethyl sulfoxide (DMSO) is difficult. However, our silica columns make a nonaqueous normal phase separation possible.

Application #:
TI0206
Type:
Application Note
Categories:
LC-MS Application for Calcium Antagonist
Compounds:
diltiazem HCl
Column(s):
Unison UK-C8 (50 x 2.0mm)

25fg of the calcium antagonist diltiazem HCl can be quantitated by utilizing our 3um C8 column and a sensitive LC-MS/MS detector.

Application #:
TI0205
Type:
Application Note
Categories:
LC-MS Application for Antiseptic Substance
Compounds:
chlorhexidine
Column(s):
Unison UK-C8 (50 x 2.0mm)

2.5pg of the disinfectant chlorhexidine are measured with an LC-MS/MS analysis using our 3um C8 column.

Application #:
TI0201
Type:
Application Note
Categories:
Non-Steroidal Anti-Inflammatory Drugs
Compounds:
oxyphenbutazone
ketoprofen
phenylbutazone
naproxen
flunixin
meclofenamic acid sodium salt
Column(s):
Cadenza CD-C18 (150 x 2.0mm)

Analysis of 6 non-steroidal anti-inflammatory drugs under standard LC-MS conditions.

Application #:
TI0200
Type:
Application Note
Categories:
Out of elution order by electrostatic interaction
Compounds:
Column(s):
Cadenza CD-C18 (75 x 4.6mm)
Unison UK-C18 (75 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

The effect of electrostatic interaction on retention. Hydrophobic interaction, which depends on hydrogen bonding capacity and dipole-dipole interaction, affects the retention time of analysis on different columns.

Application #:
TI0199
Type:
Application Note
Categories:
Adrenergic Amines
Compounds:
octopamine
synephrine
Column(s):
Unison UK-C18 (75 x 2.0mm)

Separation of synephrine, found in the fruit of the Sour Orange Tree, and and octopamine, which operates on the sympathetic nervous system.

Application #:
TI0196
Type:
Application Note
Categories:
Digitalis Glycosides
Compounds:
digoxigenin
digoxin
digitoxigenin
digitoxin
Column(s):
Unison UK-C18 (75 x 4.6mm)

Separation of the cardiac agent digitalis glycoside and its aglycon.

Application #:
TI0186
Type:
Application Note
Categories:
Loading Capacity of Preparative Column
Compounds:
econazole nitrate
miconazole nitrate
Column(s):
Unison US-C18 (250 x 20.0mm)
Unison US-C18 (250 x 4.6mm)

Loading capacity of our versatile 20mm column is demonstrated at the laboratory level.

Application #:
TI0183
Type:
Application Note
Categories:
Adreno-corticosteroids
Compounds:
aldosterone
Column(s):
Cadenza CD-C18 (250 x 4.6mm)
Cadenza CL-C18 (250 x 4.6mm)
Unison UK-C18 (250 x 4.6mm)

Simultaneous analysis of compounds involved in the synthesis of andrenal corticosteroids.

Application #:
TI0182
Type:
Application Note
Categories:
Antifungal Drugs
Compounds:
econazole nitrate
miconazole nitrate
Column(s):
Unison UK-C18 (150 x 4.6mm)

Separation of the structurally similar antifungal drugs econazole and miconazole.

Application #:
TI0176
Type:
Application Note
Categories:
5-Fluorouracil (5-FU)
Uracil
Compounds:
uracil
5-fluorouracil
Column(s):
Cadenza CL-C18 (150 x 3.0mm)
Unison UK-C18 (150 x 3.0mm)

Reverse phase separation of the highly polar compounds uracil and fluorouracil, which is an anti-cancer drug.

Application #:
TI0173
Type:
Application Note
Categories:
Acetylsalicylic Acid
Salicylic Acid
Compounds:
acetylsalicylic acid
salicylic acid
Column(s):
Cadenza CD-C18 (150 x 4.6mm)

Application #:
TI0165
Type:
Application Note
Categories:
Antipyretic Analgesics
Compounds:
acetaminophen
caffeine
salicylamide
promethazine methylenedisalicylate
Column(s):
Unison UK-C18 (75 x 3.0mm)

Analysis of antipyretic analgesics.

Application #:
TI0161
Type:
Application Note
Categories:
Antioxidants
Compounds:
butylhydroquinone (TBHQ)
Column(s):
Unison UK-C18 (75 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Analysis of an antioxidant food additives.

Application #:
TI0142
Type:
Application Note
Categories:
Hydroquinone Isomers (Dihydroxybenzene)
Compounds:
hydroquinone
resorcinol
catechol
Column(s):
Unison UK-C18 (75 x 4.6mm)
Unison UK-C8 (75 x 4.6mm)
Unison UK-Phenyl (75 x 4.6mm)

Separation of isomers of the polymerization inhibitor hydroquinine.

Application #:
TI0085
Type:
Application Note
Categories:
High Throughput LC-MS Application for Local Anesthetic and Antiarrhythmic Drugs
Compounds:
atenolol
procaine
pindolol
metoprolol
propranolol
alprenolol
tetracaine
lidocaine
dibucaine
bupivacaine
Column(s):
Cadenza CD-C18 (30 x 2.0mm)

High throughput LC-MS analysis of local anasthetic and anti-arrhythmic drugs.

Application #:
TI0080
Type:
Application Note
Categories:
Allergy Medications
Compounds:
tranilast
epinastine
chlorpheniramine
malate
diphenhydramine
hydroxyzine pamoic salt
Column(s):
Unison US-C18 (150 x 4.6mm)

Our 5um US-C18 delivers a satisfactory peak in the separation of anti-allergy medication at neutral pH.

Application #:
TI0079
Type:
Application Note
Categories:
Allergy Medications
Compounds:
tranilast
epinastine
chlorpheniramine
malate
diphenhydramine
Column(s):
Unison UK-C18 (75 x 4.6mm)

High-speed analysis of basic anti-allergy medications with 3um UK-C18 column at neutral pH

Application #:
TI0078
Type:
Application Note
Categories:
Allergy Medications
Compounds:
tranilast
epinastine
chlorpheniramine
malate
diphenhydramine
hydroxyzine pamoic salt
Column(s):
Unison UK-Phenyl (75 x 4.6mm)

3um UK-Phenyl delivers a sharp peak in high-speed mobile phase analysis at neutral pH

Application #:
TI0077
Type:
Application Note
Categories:
Allergy Medications
Compounds:
tranilast
epinastine
chlorpheniramine
malate
diphenhydramine
hydroxyzine pamoic salt
Column(s):
Unison UK-C8 (75 x 4.6mm)

3um UK-C8 delivers a sharp peak in high-speed mobile phase analysis at neutral pH

Application #:
TI0072
Type:
Application Note
Categories:
Local Anesthetic and Angiotonic
Compounds:
phenylephrine
lidocaine
naphazoline
tetracaine
Column(s):
Unison UK-Phenyl (75 x 4.6mm)

Phenyl's high-speed analysis of basic vascular medications.

Application #:
TI0059
Type:
Application Note
Categories:
Comparison of antibiotic peak shape
Compounds:
chlortetracycline
Column(s):
Cadenza CD-C18 (150 x 4.6mm)

Cadenza delivers satisfactory peak form for difficult to separate antibiotics.

Application #:
TI0045
Type:
Application Note
Categories:
Separation comparison of Fullerenes
Compounds:
Fullerene C60
Fullerene C70
higher fullerenes
Column(s):
Cadenza CD-C18 (250 x 4.6mm)

Comparison of peaks in the separation of fullerenes.

Application #:
TI0044
Type:
Application Note
Categories:
Fullerene and Higher Fullerenes
Compounds:
Fullerene C60
Fullerene C70
higher fullerenes
Column(s):
Cadenza CD-C18 (250 x 3.0mm)

Highly sensitive analysis of fullerenes and higher fullerenes with semi-micro columns.

Application #:
TI0016
Type:
Application Note
Categories:
Acetylsalicylic acid from Tablet
Compounds:
acetylsalicylic acid
Column(s):
Cadenza CD-C18 (75 x 2.0mm)
Cadenza CD-C18 (75 x 3.0mm)
Cadenza CD-C18 (75 x 4.6mm)

High speed separation of components of cold medication, with low solvent use.

Application #:
TI0011
Type:
Application Note
Categories:
Comparison of isomer separations
Compounds:
metylparaben
ethylparaben
isopropylparaben
propylparaben
isobutylparaben
butylparaben
Column(s):
Cadenza CD-C18 (75 x 2.0mm)

Cadenza CD C18, at half the length of conventional 5um ODS columns, can deliver even better high speed separation.

Application #:
TI0010
Type:
Application Note
Categories:
Separation comparison of basic compounds
Compounds:
desipramine
imipramine
nortriptyline
amitriptyline
trimpramine
Column(s):
Cadenza CD-C18 (150 x 2.0mm)

Cadenza CD-C18 offers higher separation efficiency for basic compounds than possible with conventional columns.

Application #:
TI0009
Type:
Application Note
Categories:
LC-ESI-MS application
Compounds:
nilvadipine
nisoldipine
Column(s):
Cadenza CD-C18 (75 x 2.0mm)

High speed LC-MS separation of nivaldopine and nisoldipine at half the length of conventional columns.

Application #:
SP0028
Type:
Poster
Categories:
Biochemistry/Metabolism
Column Performance
Pharmaceuticals and Cosmetics
Amino Acids and Peptides
Compounds:
nicotinic acid
tryptophan
bromoguanosine
labetalol
aspirin
fexofenadine
reserpine
SB243213A
ibuprofen
penicillin V
Column(s):

An Evaluation of a Multi-Mode Stationary Phase for HPLC Separations Using a Multi-Component Test Mix

Application #:
SP0026
Type:
Poster
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Column Performance
Compounds:
verapamil
reserpine
propranolol
Column(s):

Evaluation of Column Retentivity with large injection volume for high sensitive and High-Throughput LC-MS/MS Quantitative Analysis

Application #:
SP0024
Type:
Poster
Categories:
LC-MS
Pharmaceuticals and Cosmetics
Direct Serum Injection
Compounds:
primidone
gabapentin
carbamazepine
oxcarbazepine
lamotrigine
levetiracetam
zonisamide
sulfamethoxazole
phenytoin
topiramate
tolbutamide
Column(s):

A simple and reliable method for simultaneous quantification of antiepileptic drugs in plasma using LC-MS/MS combined with direct injection column

Application #:
SP0023
Type:
Poster
Categories:
0
Compounds:
0
Column(s):
Intrada Amino Acid (10 x 2.0mm)
Intrada Amino Acid (50 x 3.0mm)
Intrada Amino Acid (75 x 2.0mm)
Intrada Amino Acid (100 x 3.0mm)
Intrada Amino Acid (150 x 2.0mm)
Intrada Amino Acid (150 x 3.0mm)

Development of a novel amino acids analysis column for LC-MS without derivatization

Application #:
SP0020
Type:
Poster
Categories:
0
Compounds:
0
Column(s):
Scherzo SM-C18 (100 x 2.0mm)

A Novel Separation for Ethyl Glucuronide and Ethyl Sulfate using a Multi - Mode Reversed - Phase Column

Application #:
SP0014
Type:
Poster
Categories:
0
Compounds:
0
Column(s):
Cadenza CD-C18 (50 x 2.0mm)

High Throughput Simultaneous Analysis of Immunosuppressants by ESI/ESI Dual Source Coaxial Flow Ion Source LC-MS/MS System

Application #:
JA0018
Type:
Paper
Categories:
0
Compounds:
0
Column(s):

Global proteomics and metabolomics in cancer biomarker discovery

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