CADENZA HS-C18

UPDATE: New information has been added to the Applications and User Articles tabs

Hydrophilic Polymer Exclusion Type ODS Column

Sinking ODS

FEATURES

World's first: Hydrophilic/Hydrophobic Hybrid ODS Column

Direct injection of serum (plasma)

Hydrophilic polymer exclusion/Hydrophobic small molecule adsorption

Analysis of drugs in liquid formulations

LC-MS compatible

Wide range of column sizes: Inner diameter 0.075 - 10mm / Length 10-250mm

MAIN SPECIFICATIONS

Particle size:	3μm
Base materials:	Fully porous, high-purity silica gel
Ligand:	Octadecyl group, hydrophilic group
Target molecular weight:	Exclusion above Ca. 30kDa, adsorption below
pH range:	pH 2-8
Maximum pressure:	250bar / 3,500psi / 25MPa
USP Code:	L1

There have been existing columns for directly analyzing drugs in serum, each with the following drawbacks: 1. Pre-treatment columns for column switching complicate LC system configuration. 2. Isocratic analysis columns constrained by organic solvent concentration. 3. LC-MS incompatible columns requiring phosphate buffer in the mobile phase.

Cadenza HS-C18 is the world's first hydrophilic/hydrophobic hybrid ODS column capable of direct serum injection. It excludes high molecular weight serum proteins like albumin from the packing pores, while hydrophobically retaining low molecular weight drugs within the pores and separating them by organic solvent gradient elution.

Simplifying serum pretreatment processes, it is anticipated to be applied in the field of Therapeutic Drug Monitoring (TDM) where rapid analysis is crucial. Recently, it has been widely used to control surfactant concentrations, stabilizers of monoclonal antibody formulations in high demand. Additionally, this product effectively separates hydrophilic polymers other than proteins and drugs in liquid formulations such as injectables.

Cadenza HS-C18 enables LC-MS analysis of small molecules in protein and hydrophilic polymer solutions, expected to be widely adopted in various fields including blood analysis and formulation analysis.

FEATURES

MAIN SPECIFICATIONS

[Latest Applications]

>>>See all Cadenza HS-C18 Application Database <<<

Analysis of Surfactants in Monoclonal Antibody (mAb) Formulations

LC-MS/MS Rapid Quantitative Method for Antiepileptic Drugs (AEDs) in Plasma

Non-targeted Metabolomics by LC-QTOF MS

Development of a Novel Micafungin Plasma Concentration Measurement Method by Direct Serum Injection

Practicality of Plasma Direct Injection Method

Quantitative analysis of residual aurintricarboxylic acid in biotherapeutic process streams using liquid chromatography triple quadrupole mass spectrometry

Direct Quantitation of Poloxamer 188 in Adeno-Associated Virus Products Using Reversed-Phase Chromatography With Charged Aerosol Detection

Combined Use of Calcium-channel Blockers With Ombitasvir/Paritaprevir/Ritonavir Exacerbates Peripheral Edema in Elderly Japanese Patients

Detection of 11-nor-9-carboxy-tetrahydrocannabinol in the hair of drug abusers by LC-MS/MS analysis

Change in the Binding of [11C]BU99008 to Imidazoline I2 Receptor Using Brain PET in Zucker Rats

*Radiosynthesis and in vivo evaluation of 11C-labeled BMS-193885 and its desmethyl analog as PET tracers for neuropeptide Y1 receptors

Development of a liquid chromatography/tandem mass spectrometry method for monitoring of long-term exposure to parabens

Developing new PET tracers to image the growth hormone secretagogue receptor 1a (GHS-R1a)

Non-targeted metabolic profiling analysis for diagnosis of internet/smartphone addiction disorder

Direct injection LC-MS/MS method for the determination of teicoplanin in human plasma

*One-Pot Esterification and Amidation of Phenolic Acids

Influence of Dosing Time on the Efficacy and Safety of Finasteride in Rats

Direct determination of residual Pluronic F-68 in in-process samples from monoclonal antibody preparations by high performance liquid chromatography

Direct-injection HPLC method of measuring micafungin in human plasma using a novel hydrophobic/hydrophilic hybrid ODS column.

注射用エンドキサンの揮発性に関する調査

Influence of water and food consumption on inadvertent antibiotics intake among general population

Influence of a five-day vegetarian diet on urinary levels of antibiotics and phthalate metabolites: A pilot study with “Temple Stay” participants

Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach

Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and AKT activation.

Biochemical, Functional, and Pharmacological Characterization of AT-56, an Orally Active and Selective Inhibitor of Lipocalin-type Prostaglandin D Synthase

Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin

Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells.

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