Imtakt USA - Next Generation HPLC Columns


Imtakt USA Newsletter	December 2011
In This Issue
1. Scherzo SW-C18 and Scherzo SM-C18 can separate acidic and basic pharmaceutical compounds 2. The Standard Cadenza CD-C18 column excels in fast separation and structural recognition 3. Happy Holidays from Imtakt USA
Scherzo SW-C18 and Scherzo SM-C18 can separate acidic and basic pharmaceutical compounds
The analysis of acidic and basic compounds is important in the study of pharmaceuticals. It is sometimes difficult to analyze both acidic and basic compounds on a single standard C18 column. Imtakt's Scherzo SM-C18 and Scherzo SW-C18 HPLC columns can separate acidic ibuprofen and basic chlorpheniramine simultaneously. This is possible because of the unique blend of anion ligands, cation ligands, and reverse phase ligands. As shown in the link below, Scherzo SW-C18 (containing a small amount of strong ionic ligands) retains ibuprofen more than Scherzo SM-C18 (containing weak ionic ligands). In this application, Scherzo SM-C18 works well with isocratic elution, whereas Scherzo SW-C18 excels with gradient elution. Separation of acidic Ibuprofen and basic Chlorpheniramine: http://imtakt.com/TecInfo/TI690E.pdf
The Standard Cadenza CD-C18 column excels in fast separation and structural recognition
Imtakt's standard Cadenza CD-C18 HPLC column is LC/MS compatible and can separate small molecules with faster run times than our competitors' standard C18 columns. As shown in the links below, chloramphenicol and clenbuterol elute at 6.5 minutes and 5 minutes, respectively. LC/MS separation of chloramphenicol: http://www.imtaktusa.com/site_media/files/technical_information/TI658E.pdf LC/MS separation of clenbuterol: http://www.imtaktusa.com/site_media/files/technical_information/TI656E.pdf Not only can the standard Cadenza CD-C18 HPLC column separate small molecules in short run times, it can also recognize slight structural differences. As shown in the link below, the retention times of the dyes leucomalachite green and malachite green differ by over 5 minutes. The only difference between these two molecules is a positive charge and the placement of double bonds. LC/MS separation of [leuco]malachite green: http://www.imtaktusa.com/site_media/files/technical_information/TI657E.pdf
Happy Holidays from Imtakt USA
On behalf of all of us here at Imtakt USA, we would like to wish you a very happy holiday season and a happy new year! Thanks to customers like you, we had a fantastic 2011 and look forward to working with you next year and the years to come!