We are proud to introduce two new additions to the Scherzo Column Family:
Scherzo SS-C18, Strong Ion Exchange C18: The SS-C18 column consists of a large density of strong cationic and anionic ligands as well as C18 ligands.
Scherzo SW-C18, Weak Ion Exchange C18: The SW-C18 consists of a lower density of strong cationic and anionic ligands as well as C18 ligands.
Like our Scherzo SM-C18, these columns also have ODS, anion, and cation ligands. But now, a wider range of polar ionic compounds can be retained by these two variations of our Scherzo SM-C18 column. Retention and elution on the Scherzo columns can be controlled by adjusting the pH and/or salt concentration.
Click here to see the Technical Report for the newest Scherzo columns
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Weak ionic compounds, such as zwitterionic compounds and catecholamines, can be very difficult to retain on conventional ODS columns. Due to its strong ionic ligands, Scherzo SS-C18 improves retention for weak ionic compounds. See the data in the application links below:
Zwitterionic Compounds:
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Catecholamines:
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Strong ionic compounds are difficult to elute on conventional ODS columns. Scherzo SW-C18 contains a small amount of strong ionic ligands, which enable the elution of strong polar compounds, such as siRNA. Application data shows that the SW-C18 generates multiple peaks for siRNA compounds which may include different structural compounds. See below for details:
siRNA:
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